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. 2019 May 31;12:144. doi: 10.3389/fnmol.2019.00144

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Copyright © 2019 Welch, Forster, Atlas and Baro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased SUMOylation at K579 mediates the decrease in I_A G_max. (A,C,E) Representative current traces for the indicated stable mutant cell line in each treatment group. (B,D,F) Bar graphs representing normalized I_A G_max. Each data point is one cell, and cells in each treatment group were obtained from ≥3 independent transfections. All data points were normalized by the mean value for the mCherry treatment group. Asterisk, significantly different. Kv4.2g K437R+K579R: control, 1.0 ± 0.14; SUMO+Ubc9, 0.91 ± 0.12; t-test p = 0.63. Kv4.2g K437R: control, 1.0 ± 0.080; SUMO+Ubc9, 0.66 ± 0.12; t-test p = 0.035. Kv4.2g K579R: control, 1.0 ± 0.1656; SUMO+Ubc9, 1.02 ± 0.1141; Mann-Whitney U p = 0.4715.