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. 2019 May 31;10:660. doi: 10.3389/fphys.2019.00660

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Copyright © 2019 Ge, Wang, Zhang, Li and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tempol protects against acetaminophen-induced acute hepatotoxicity via the PI3K/Akt/Nrf2 pathway in mice. (A) Protein expression of Nrf 2 in the nucleus of liver from the control mice (control), vehicle-treated hepatotoxicity mice (APAP), and tempol-treated hepatotoxicity mice (APAP + tempol). (B) Protein expressions of PI3K, Akt, and HO-1 and phosphorylation of PI3K and Akt in liver from three groups. Data are mean ± SEM. *p < 0.05 vs. control, ^#p < 0.05 vs. APAP, ***p < 0.001 vs. control, ^###p < 0.001 vs. APAP, n = 4.