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. 2019 May 31;13:241. doi: 10.3389/fncel.2019.00241

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Copyright © 2019 Wang, Zhou, Li, Xu, Xie, Sun, Rodriguez, Zhang, Song, Wang, Blomgren and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Atg7 KO reduced irradiation-induced OPC loss. (A) Mouse OPCs in the cerebellum after irradiation were immunostained for PDGFRα. (B) Quantitative analysis of PDGFRα-labeled cells in the cerebellar white matter. (C) The mRNA level of Olig2, Cldn11, CNP, and MBP was significantly greater in the Atg7 KO mice compared with WT mice under both physiological conditions and after irradiation. n = 7/group for immunohistochemistry staining; n = 5/group for the qRT-PCR assays. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.