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. 2019 Feb 10;27(6):1166–1182. doi: 10.1016/j.ymthe.2019.02.002

Figure 1.

Figure 1

miR-577 Is Upregulated in GC and Associated with Poor Prognosis

(A) qRT-PCR analysis of miR-577 expression in 36 pairs of GC specimens and normal tissues. miR-577 was normalized to endogenous U6 RNA and expressed relative to their respective match normal tissues. (B) The expression of miR-577 in 36 pairs of GC specimens and normal tissues. **p < 0.01. (C) The miR-577 expression in TNM stage I and stage II GC tissues and stage III and stage IV GC tissues. *p < 0.05. (D) The miR-577 expression in GC tissues with or without metastasis. ***p < 0.001. (E) In situ hybridization (ISH) analysis of miR-577 expression in 153 human normal gastric tissues and GC specimens from TNM stage I–IV patients. (F) Frequency of low and high miR-577 expressions categorized by TNM stage, tumor invasion, lymph node metastasis, distant metastasis, recurrence, and death (p = 0.022, p = 0.019, p = 0.027, p = 0.002, p = 0.029, and p = 0.030, respectively). Patients were separated into high- and/or low-expression groups by the expression score of the miR-577. *p < 0.05; **p < 0.01. (G) Retrospective analysis of Kaplan-Meier plots for miR-577 expression in association with disease-free survival and overall survival. (H) qRT-PCR analysis of miR-577 expression in GC cell lines and an immortalized human gastric cell line. Data represent mean ± SD.