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. 2019 Apr 9;27(6):1195–1205. doi: 10.1016/j.ymthe.2019.04.002

Figure 6.

Figure 6

Properties of the OMR in TKO Mice Mediated by CoChRs and Red-Shifted ChRs

(A and B) A homemade optomotor system (A) that uses blue (470 nm), green (520 nm), yellow (590 nm), or natural white-light (4,500 K) LEDs as the light illumination source (B). (C) The spatial frequency-dependent threshold light intensity curves for wt-CoChR- (n = 5), CoChR-LC- (n = 7), and CoChR-3M-treated mice (n = 7). The OMR was elicited by blue LEDs. (D) The light intensity curves for CoChR-3M-treated mice (n = 4) measured 1 and 12 months after virus vector injection. (E) Comparison of the frequency-dependent threshold light intensity curves for CoChR-3M- (the same data from C), ReaChR- (n = 7), and Chrimson-treated mice (n = 6). The OMR for ReaChR- and Chrimson-treated mice was elicited by green and yellow LEDs, respectively. (F) The frequency-dependent threshold light intensity curves for CoChR-3M- (n = 7), ReaChR- (n = 7), and Chrimson-treated mice (n = 6) elicited with natural white LEDs as the light illumination source. The dashed line estimates the light intensity level produced by a normal LCD monitor. All data are presented as means ± SD from the indicated number of animals.