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. 2019 Jun 5;39(23):4489–4510. doi: 10.1523/JNEUROSCI.2881-18.2019

Figure 3.

Figure 3.

p75NTR expression in cortical PV cells decreases during the first postnatal month. A, B, Cortical slices from P14 (A) and P26 (B) WT mice immunostained with PV to label PV cells (A1, B1; green) and PLA-mediated labeling for p75NTR (A2, B2; red dots, henceforth indicated in figures as p75). White arrows indicate PLA signals that colocalize with PV signals (A1–A3, B1–B3). Yellow arrowheads indicate PLA signals without PV colocalization (A1–A3, B1–B3). At both ages, p75NTR signal can be found in both PV-positive cell somata and putative boutons. Scale bar, 10 μm. C, Quantification of p75NTR PLA intensity in PV cells at different postnatal ages shows a significant decline of p75NTR signal in PV cells and boutons between P14 and P26 (unpaired t test with Welch's correction, df = 22.44, t = 7.642, ***p < 0.0001). n = 4 animals for each age point.