Table 4.
Ribbon or GluA3 volume per synapse (μm3, all paired synapses) for unexposed or 2 weeks after 100 dB SPL exposure in midcochlea of Vglut3WT, Vglut3+/−, or Vglut3KOa
| Genotype | Unexposed |
2 weeks |
Kolmogorov–Smirnov test exposure | ||
|---|---|---|---|---|---|
| Mean ± SD | Median | Mean ± SD | Median | ||
| Ribbons | |||||
| Vglut3WT | 0.098 ± 0.079 | 0.076 | 0.123 ± 0.08 | 0.101 | p = 9e-33 (0.3)* |
| Vglut3+/− | 0.106 ± 0.095 | 0.078 | 0.117 ± 0.092 | 0.096 | p = 2e-7 (0.2)* |
| Vglut3KO | 0.122 ± 0.088 | 0.099 | 0.155 ± 0.116 | 0.127 | p = 2e-8 (0.3)* |
| Kolmogorov–Smirnov test WT ± | p = 0.2 | p = 5e-12 (0.1) | |||
| Kolmogorov–Smirnov test WT KO | p = 2e-17 (0.3)* | p = 3e-8 (0.3)* | |||
| GluA3 | |||||
| Vglut3WT | 0.377 ± 0.182 | 0.355 | 0.385 ± 0.188 | 0.354 | p = 0.3 |
| Vglut3+/− | 0.413 ± 0.209 | 0.374 | 0.448 ± 0.225 | 0.414 | p = 2e-4 (0.2)* |
| Vglut3KO | 0.542 ± 0.259 | 0.52 | 0.63 ± 0.342 | 0.575 | p = 4e-4 (0.2)* |
| Kolmogorov–Smirnov test WT ± | p = 1e-4 (0.1) | p = 3e-10 (0.3)* | |||
| Kolmogorov–Smirnov test WT KO | p = 6e-73 (0.8)* | p = 5e-50 (0.9)* | |||
aValues are number of animals-images-synapses unexposed: WT, 4-12-2407; HET, 3-8-1480; KO, 6-13-1305. Number of animals-images-synapses 2 weeks after exposure: WT, 3-8-1365; HET, 4-10-1191; KO, 3-6-515. p value (effect size; Kolmogorov–Smirnov test).
*Comparisons with p values < 0.05 and effect size ≥ 0.2.