Figure 1.

Experimental design and recording locations. A, Schematic of W-track spatial alternation task. Animals run in a W-shaped maze, alternating between runs to the center arm and to the two alternating outer arms for liquid food reward (see Materials and Methods for more details). B, C, Representative histological images of recording sites marked by lesions (arrows) in dorsal CA1 (B) and medial PFC (PrL region; C). Boundaries indicate extent of tetrode locations identified in dorsal CA1 and PFC in all five animals. Scale bars, 500 μm.