Figure 4.

KA-SE induces increased numbers of FJC-positive cells in TrkB^Shc/Shc compared with WT mice. A, Representative images (top) of FJC staining in CA3 (the region with greatest FJC staining in this model) of middle hippocampus for both WT and TrkB^Shc/Shc mice 24 h after SE. Scale bar, 50 μm. Insets, High-magnitude images (bottom) of FJC-positive neurons in hippocampal CA3 subfields. Scale bar, 50 μm. The numbers of FJC-positive cells in CA3 of middle (B), rostral (C), and caudal (D) hippocampus was quantified. Significantly more FJC-positive cells were found in TrkB^shc/shc (n = 11) versus WT (n = 15) mice. Data are presented as mean ± SEM and analyzed by unpaired Student's t test. *p < 0.05.