. 2019 Jun 5;39(23):4566–4575. doi: 10.1523/JNEUROSCI.2370-18.2019

Table 1.

Demographic and cognitive differences between groups

	High YoE (N = 48)	Low YoE (N = 74)	Group differences
Age, y	67.2 ± 3.2	68.9 ± 3.6	U = 2.850
Age, y	67.2 ± 3.2	68.9 ± 3.6	p = 0.005^a ^*
Gender, F/M	24/24	63/11	χ² = 17.568
Gender, F/M	24/24	63/11	p < 0.001^b ^*
YoE	15.7 ± 1.7	9.0 ± 2.6	U = 9.480
YoE	15.7 ± 1.7	9.0 ± 2.6	p < 0.001^a ^*
MMSE	29.6 ± 0.7	29.4 ± 1	U = 0.656
MMSE	29.6 ± 0.7	29.4 ± 1	p = 0.512^a
Memory domain	0.39 ± 0.94	−0.25 ± 0.96	t = 3.122
Memory domain	0.39 ± 0.94	−0.25 ± 0.96	p = 0.002^c ^*
Frontal lobe domain	0.55 ± 0.66	−0.30 ± 1.02	t = 4.427
Frontal lobe domain	0.55 ± 0.66	−0.30 ± 1.02	p < 0.001^c ^*

Data are presented as mean ± SD. F/M, Female/male. MMSE represent direct values, Memory and Frontal lobe scores were composite factors calculated using PCA. Statistical comparisons reflect the results after these variables were further adjusted by age, gender, and for the test group variable (see Materials and Methods).[1]

^ap values were obtained by Mann–Whitney's U test pairwise comparisons (nonparametric data).

^bp values were obtained by χ² test (categorical data).

^cp values were obtained by two-sample t test.

*Significant differences.