Table 2.
GSEA
| Gene set | NES | FDR q-val | Size | GSEA ID | URL |
|---|---|---|---|---|---|
| 1. Ionotropic neurotransmission | |||||
| GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY | 2.159 | 0.012 | 25 | M18911 | http://amigo.geneontology.org/amigo/term/GO:0005230 |
| GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY | 2.204 | 0.011 | 28 | M18473 | http://amigo.geneontology.org/amigo/term/GO:0005231 |
| GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY | 1.999 | 0.048 | 29 | M17983 | http://amigo.geneontology.org/amigo/term/GO:0022835 |
| GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY | 2.049 | 0.031 | 79 | M18363 | http://amigo.geneontology.org/amigo/term/GO:0030594 |
| 2. NEUROPEPTIDE SIGNALING | |||||
| GO_NEUROPEPTIDE_HORMONE_ACTIVITY | 2.057 | 0.033 | 68 | M18214 | http://amigo.geneontology.org/amigo/term/GO:0005184 |
| GO_NEUROPEPTIDE_RECEPTOR_BINDING | 2.120 | 0.012 | 51 | M18007 | http://amigo.geneontology.org/amigo/term/GO:0071855 |
| 3. Transmembrane signaling | |||||
| GO_RESPONSE_TO_AMMONIUM_ION | 2.037 | 0.033 | 26 | M10335 | http://amigo.geneontology.org/amigo/term/GO:0060359 |
| 4. Purinergic signaling | |||||
| GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY | 1.991 | 0.049 | 28 | M16435 | http://amigo.geneontology.org/amigo/term/GO:0035587 |
| 5. Immune response | |||||
| GO_MYELOID_DENDRITIC_CELL_ACTIVATION | 2.124 | 0.014 | 55 | M16283 | http://amigo.geneontology.org/amigo/term/GO:0001773 |
| GO_MACROPHAGE_ACTIVATION | 2.133 | 0.016 | 75 | M13410 | http://amigo.geneontology.org/amigo/term/GO:0042116 |
| 6. Vesicle trafficking | |||||
| GO_CLATHRIN_COATED_VESICLE_MEMBRANE | 2.013 | 0.043 | 31 | M17518 | http://amigo.geneontology.org/amigo/term/GO:0030665 |
GSEA results identifying 11 gene sets belonging to 6 larger functional clusters.