Table 3.
Leading-edge genes of positively enriched gene sets in education-related cortical areas
| Gene | Rank in gene list | Delta-score | Functional group |
|---|---|---|---|
| CHRNA1 | 2073 | 0.055 | Ionotropic neurotransmission |
| GABRB3 | 4013 | 0.034 | Ionotropic neurotransmission |
| GABRB1 | 1966 | 0.057 | Ionotropic neurotransmission |
| CHRNA2 | 383 | 0.112 | Ionotropic neurotransmission |
| CHRNA4 | 3822 | 0.035 | Ionotropic neurotransmission |
| GRIK5 | 3748 | 0.036 | Ionotropic neurotransmission |
| CHRNA6 | 30 | 0.228 | Ionotropic neurotransmission |
| GRIK3 | 2188 | 0.053 | Ionotropic neurotransmission |
| GRIK4 | 1311 | 0.069 | Ionotropic neurotransmission |
| GRIK1 | 725 | 0.090 | Ionotropic neurotransmission |
| GRIK2 | 3892 | 0.035 | Ionotropic neurotransmission |
| CHRND | 2309 | 0.051 | Ionotropic neurotransmission |
| GLRA2 | 2534 | 0.049 | Ionotropic neurotransmission |
| GLRA3 | 193 | 0.139 | Ionotropic neurotransmission |
| PTK2B | 1126 | 0.074 | Ionotropic neurotransmission |
| GABRD | 3157 | 0.042 | Ionotropic neurotransmission |
| GRIA4 | 3367 | 0.040 | Ionotropic neurotransmission |
| GABRQ | 1422 | 0.067 | Ionotropic neurotransmission |
| CHRNB2 | 3933 | 0.035 | Ionotropic neurotransmission |
| GRID2 | 3549 | 0.038 | Ionotropic neurotransmission |
| CHRNB3 | 172 | 0.145 | Ionotropic neurotransmission |
| GABRA5 | 2148 | 0.054 | Ionotropic neurotransmission |
| GABRA3 | 2268 | 0.052 | Ionotropic neurotransmission |
| HTR3A | 1185 | 0.072 | Ionotropic neurotransmission |
| HTR3B | 107 | 0.166 | Ionotropic neurotransmission |
| GRIN2C | 886 | 0.083 | Ionotropic neurotransmission |
| GRIN2B | 1247 | 0.071 | Ionotropic neurotransmission |
| GRIN2D | 3196 | 0.041 | Ionotropic neurotransmission |
| GRIN3A | 293 | 0.122 | Ionotropic neurotransmission |
| GRIA3 | 4508 | 0.030 | Ionotropic neurotransmission |
| CHRM3 | 1533 | 0.064 | Ionotropic neurotransmission |
| CHRM1 | 695 | 0.092 | Ionotropic neurotransmission |
| CHRM5 | 841 | 0.084 | Ionotropic neurotransmission |
| HRH3 | 1832 | 0.059 | Ionotropic neurotransmission |
| DRD4 | 679 | 0.092 | Ionotropic neurotransmission |
| UCN | 2726 | 0.046 | Neuropeptide signaling |
| GRP | 61 | 0.194 | Neuropeptide signaling |
| CCK | 327 | 0.118 | Neuropeptide signaling |
| TRH | 1531 | 0.064 | Neuropeptide signaling |
| ADCYAP1 | 723 | 0.090 | Neuropeptide signaling |
| CORT | 2852 | 0.045 | Neuropeptide signaling |
| GAL | 13 | 0.300 | Neuropeptide signaling |
| NPY | 1125 | 0.074 | Neuropeptide signaling |
| PNOC | 98 | 0.170 | Neuropeptide signaling |
| NPPA | 1561 | 0.064 | Neuropeptide signaling |
| CRH | 308 | 0.120 | Neuropeptide signaling |
| VIP | 1573 | 0.064 | Neuropeptide signaling |
| HCRT | 2355 | 0.051 | Neuropeptide signaling |
| EDN1 | 1281 | 0.070 | Neuropeptide signaling |
| CCKBR | 2641 | 0.048 | Neuropeptide signaling |
| GHRH | 847 | 0.084 | Neuropeptide signaling |
| NMU | 27 | 0.235 | Neuropeptide signaling |
| SHANK1 | 746 | 0.089 | Neuropeptide signaling |
| KCNC2 | 1181 | 0.072 | Transmembrane signaling |
| SLC34A1 | 187 | 0.140 | Transmembrane signaling |
| OPRM1 | 255 | 0.127 | Transmembrane signaling |
| ASS1 | 1852 | 0.058 | Transmembrane signaling |
| PPP1R9B | 3268 | 0.041 | Transmembrane signaling |
| CCNA2 | 976 | 0.079 | Transmembrane signaling |
| CRHBP | 1198 | 0.072 | Transmembrane signaling |
| HRH1 | 674 | 0.092 | Transmembrane signaling |
| GNA15 | 3229 | 0.041 | Transmembrane signaling |
| GNAQ | 2989 | 0.043 | Transmembrane signaling |
| GNB1 | 1626 | 0.062 | Transmembrane signaling |
| RGS10 | 910 | 0.082 | Transmembrane signaling |
| RGS8 | 1677 | 0.061 | Transmembrane signaling |
| CDK5R1 | 2769 | 0.046 | Transmembrane signaling |
| P2RY12 | 95 | 0.172 | Purinergic signaling |
| P2RX7 | 1776 | 0.060 | Purinergic signaling |
| P2RY13 | 33 | 0.224 | Purinergic signaling |
| P2RX6 | 263 | 0.126 | Purinergic signaling |
| P2RY6 | 309 | 0.120 | Purinergic signaling |
| P2RX5 | 1255 | 0.071 | Purinergic signaling |
| P2RY11 | 1570 | 0.064 | Purinergic signaling |
| GPR34 | 271 | 0.124 | Purinergic signaling |
| ADORA3 | 155 | 0.148 | Purinergic signaling |
| PTAFR | 961 | 0.080 | Purinergic signaling |
| GNAI2 | 1428 | 0.067 | Purinergic signaling |
| PYCARD | 517 | 0.101 | Immune response |
| BATF3 | 985 | 0.079 | Immune response |
| TGFB1 | 564 | 0.098 | Immune response |
| PYDC1 | 505 | 0.102 | Immune response |
| DOCK2 | 461 | 0.105 | Immune response |
| DHRS2 | 122 | 0.160 | Immune response |
| TM7SF4 | 253 | 0.127 | Immune response |
| CX3CR1 | 269 | 0.125 | Immune response |
| ZAP70 | 545 | 0.099 | Immune response |
| TYROBP | 653 | 0.093 | Immune response |
| SYK | 295 | 0.121 | Immune response |
| CD93 | 777 | 0.088 | Immune response |
| SLC11A1 | 950 | 0.080 | Immune response |
| TLR7 | 1188 | 0.072 | Immune response |
| AIF1 | 96 | 0.171 | Immune response |
| CLU | 1748 | 0.060 | Immune response |
| TLR3 | 994 | 0.078 | Immune response |
| CX3CL1 | 1772 | 0.060 | Immune response |
| SNCA | 1060 | 0.076 | Immune response |
| RAB3A | 2097 | 0.055 | Vesicle trafficking |
| TYRP1 | 328 | 0.118 | Vesicle trafficking |
| CLTA | 3693 | 0.037 | Vesicle trafficking |
| AP2A1 | 1624 | 0.062 | Vesicle trafficking |
| KIAA1199 | 3293 | 0.041 | Vesicle trafficking |
| AP2A2 | 2058 | 0.055 | Vesicle trafficking |
| NCALD | 511 | 0.101 | Vesicle trafficking |
| NRGN | 229 | 0.132 | Vesicle trafficking |
| CLTCL1 | 693 | 0.092 | Vesicle trafficking |
| AP2S1 | 666 | 0.093 | Vesicle trafficking |
| SLC17A7 | 2179 | 0.053 | Vesicle trafficking |
| FCGR1A | 1250 | 0.071 | Vesicle trafficking |
| FCGR1B | 257 | 0.127 | Vesicle trafficking |
| HLA-DQA2 | 2184 | 0.053 | Vesicle trafficking |
| LDLR | 3312 | 0.040 | Vesicle trafficking |
| AP1M2 | 1516 | 0.065 | Vesicle trafficking |
| AP2M1 | 2364 | 0.051 | Vesicle trafficking |
| HLA-DQA1 | 4017 | 0.034 | Vesicle trafficking |
| AP1M1 | 2776 | 0.046 | Vesicle trafficking |
| HLA-DPA1 | 4290 | 0.032 | Vesicle trafficking |
| CD74 | 708 | 0.091 | Vesicle trafficking |
| HLA-DRB5 | 3488 | 0.039 | Vesicle trafficking |
| HLA-DRB4 | 8 | 0.312 | Vesicle trafficking |
| DBNL | 764 | 0.088 | Vesicle trafficking |
| FZD5 | 4176 | 0.033 | Vesicle trafficking |
| SLC32A1 | 4411 | 0.031 | Vesicle trafficking |
| WNT5A | 4491 | 0.031 | Vesicle trafficking |
| AP1B1 | 3964 | 0.035 | Vesicle trafficking |
| AP3B2 | 3468 | 0.039 | Vesicle trafficking |
| HLA-DPB1 | 2465 | 0.050 | Vesicle trafficking |
| HLA-DRA | 62 | 0.193 | Vesicle trafficking |
| CD9 | 3327 | 0.040 | Vesicle trafficking |
| HLA-DQB1 | 239 | 0.130 | Vesicle trafficking |