Figure 13.

sEHIs produce rapid antidepressant-like effects. A, The effects of TPPU, TUCB, and vehicle in the FST when mice were examined 1 h after the injection (i.p.). B, Treatments with sEHIs had no effect on locomotion. C, D, CSDS paradigm. Avoidance behaviors of the mice after 3 or 7 d treatment with vehicle, IMI, TPPU, or TUCB (i.p.). E, CMS paradigm. Measurements of sucrose preference (left), the physical state of the coat (middle) and body weight (right), showing baseline followed by poststress measurements conducted each week for the mice treated with vehicle, TPPU, TUCB, or IMI (i.p.). Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. N.S., not significant.