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. 2019 Jun 5;39(23):4606–4623. doi: 10.1523/JNEUROSCI.3069-18.2019

Figure 2.

Figure 2.

Dysfunction of EET signaling in human depression and mouse CSDS. A, Western blots showing the expression of sEH monomer and oligomer in the BA24 of patients with MDD and matched controls. B, Quantification of the Western blot results in BA24 and BA47. Hollow circle represents male. Solid circle represents female. C, Western blot analyses of sEH in the mPFC and hippocampus (Hipp.) after CSDS. D, E, Quantifications of sEH monomer and oligomer in the mPFC and hippocampus after CSDS. F, Measurement of the levels of 14,15-DHET hydrolyzed by sEH in the mPFC and hippocampus after CSDS. Cont., Control; Sus., susceptible; Res., resilient. Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.