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. 2019 Jun 5;39(23):4606–4623. doi: 10.1523/JNEUROSCI.3069-18.2019

Figure 3.

Figure 3.

Antidepressant-like effects are induced by enhancement of EET signaling. A, Schematic representation of the experimental design for intracerebroventricular injections. B, Immobility of adult C57BL/6J mice injected with different dosages of TPPU, TUCB, or vehicle in the FST. C, No effect on spontaneous locomotor activity was observed following an intracerebroventricular infusion of different dosages of TPPU, TUCB, or vehicle. D, Immobility of adult C57BL/6J mice injected with different dosages of 14,15-EET in the FST. E, Infusions of 14,15-EET had no effect on locomotion. F, G, The intracerebroventricular infusions of 5,6-, 8,9-, or 11,12-EET did not produce antidepressant-like effects in the FST. H, Schematic paradigm and the antidepressant-like effect of TPPU (intracerebroventricular) in the CSDS model. Data are mean ± SEM. *p < 0.05, ***p < 0.001. N.S., not significant.