Figure 7.

Deletion of Ephx2 in adult astrocytes induces resilience to stress. A, Antidepressant-like effect of Ephx2 deletion in adult astrocytes in the FST. B, Fgfr3-Ephx2^−/− and littermate control mice were detected in the open field test. C, Fgfr3-Ephx2^−/− mice were less susceptible to social defeat stress. D–G, Behavioral responses of Fgfr3-Ephx2^−/− mice and littermate controls in the elevated plus maze test. H, I, Animals were examined in the light-dark box test. Data are mean ± SEM. *p < 0.05, **p < 0.01.