Skip to main content
. 2019 Jun 5;39(23):4606–4623. doi: 10.1523/JNEUROSCI.3069-18.2019

Figure 8.

Figure 8.

Enhancement of EET signaling in adult astrocytes in the mPFC produces antidepressant-like effects. A, Experimental timeline (left) and bilateral injection sites in the mPFC (middle) with an image of EGFP expression 2 weeks after injection (right). Scale bar, 0.5 mm. B, Confocal images of the mPFC of adult Fgfr3-tdTomato mice 14 d after viral injection. Green represents pLenti-EGFP. Red represents tdTomato. Blue represents DAPI. Scale bar, 20 μm. C, Levels of sEH in the mPFC of adult C57BL/6J mice injected with pLenti-shRNAs. D, Immobility of adult C57BL/6J mice injected with pLenti-Ephx2-shRNAs or control shRNA. E, Spontaneous locomotor activity of mice with bilateral mPFC infusions of pLenti-shRNAs. Data are mean ± SEM. *p < 0.05, ***p < 0.001.