Table 2.
Brain-regional EET levels in CSDS paradigma
| Structure | Group | EETs (ng/g) | 5,6-EET (ng/g) | 8,9-EET (ng/g) | 11,12-EET (ng/g) | 14,15-EET (ng/g) |
|---|---|---|---|---|---|---|
| mPFC | Control | 5.089 ± 0.225 | 1.710 ± 0.185 | 0.604 ± 0.187 | 0.946 ± 0.117 | 1.829 ± 0.097 |
| Susceptible | 3.349 ± 0.419* | 1.219 ± 0.315 | 0.453 ± 0.116 | 0.575 ± 0.099 | 1.101 ± 0.077** | |
| Resilient | 4.923 ± 0.649 | 1.813 ± 0.456 | 0.830 ± 0.201 | 0.877 ± 0.156 | 1.404 ± 0.137 | |
| Hippocampus | Control | 4.126 ± 0.352 | 1.448 ± 0.280 | 0.694 ± 0.159 | 0.905 ± 0.132 | 1.078 ± 0.121 |
| Susceptible | 3.642 ± 0.150 | 1.130 ± 0.233 | 0.748 ± 0.144 | 0.696 ± 0.140 | 1.067 ± 0.133 | |
| Resilient | 4.217 ± 0.407 | 1.295 ± 0.300 | 1.077 ± 0.254 | 0.702 ± 0.071 | 1.142 ± 0.102 | |
| NAc | Control | 5.069 ± 0.499 | 1.764 ± 0.274 | 0.776 ± 0.294 | 0.983 ± 0.094 | 1.546 ± 0.245 |
| Susceptible | 4.928 ± 0.584 | 1.739 ± 0.399 | 0.871 ± 0.229 | 0.937 ± 0.264 | 1.380 ± 0.151 | |
| Resilient | 5.645 ± 0.765 | 1.940 ± 0.281 | 0.937 ± 0.237 | 1.142 ± 0.305 | 1.627 ± 0.182 | |
| Striatum | Control | 3.151 ± 0.250 | 0.932 ± 0.232 | 0.663 ± 0.137 | 0.548 ± 0.107 | 1.008 ± 0.095 |
| Susceptible | 2.845 ± 0.245 | 0.931 ± 0.171 | 0.269 ± 0.099 | 0.452 ± 0.108 | 1.193 ± 0.091 | |
| Resilient | 3.348 ± 0.330 | 1.192 ± 0.258 | 0.571 ± 0.154 | 0.612 ± 0.128 | 0.974 ± 0.131 | |
| Cerebral cortex (without the mPFC) | Control | 6.137 ± 0.511 | 2.084 ± 0.231 | 1.396 ± 0.334 | 0.941 ± 0.167 | 1.715 ± 0.262 |
| Susceptible | 5.106 ± 0.442 | 1.463 ± 0.190 | 0.518 ± 0.212* | 1.368 ± 0.133 | 1.756 ± 0.292 | |
| Resilient | 6.845 ± 0.606 | 2.548 ± 0.430 | 1.302 ± 0.247 | 1.254 ± 0.122 | 1.741 ± 0.122 |
aEET levels detected in the mPFC, hippocampus, NAc, striatum, and cerebral cortex when mice were killed 24 h after the CSDS. Data are mean ± SEM; n = 8–10.
*p < 0.05 compared with control (one-way ANOVA);
**p < 0.001 compared with control (one-way ANOVA).