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. 2019 May 31;10:528. doi: 10.3389/fgene.2019.00528

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Copyright © 2019 Liu, Zhang, Li, Ou, Yuan, Zhang, Fan and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in donors and recipients respectively. Total > 240,000 markers were analyzed toward natural log of dose-normalized tacrolimus trough concentrations between donors and recipients in the first 4 weeks with adjustment of age, donor gender, gender and BMI. All SNPs were shown in order from chromosome 1 to 23 (not including Y chromosome). (A) Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in donors in week 1. (B) Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in donors in week 2. (C) Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in donors in week 3. (D) Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in donors in week 4. (E) Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in recipients in week 1. (F) Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in recipients in week 2. (G) Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in recipients in week 3. (H) Manhattan plots of single-nucleotide polymorphisms (SNPs) associated with ln(TAC C₀/D ratio) in recipients in week 4.