Figure 5.

Examples of pathological sparks with disorder leak emerging at higher λ (i.e., higher P_o) in a free-running JSR. (A) Normal supercritical spark with no leak is shown. (B) Oscillatory leak near β criticality is shown. (C) Persistent disorder leak in the subcritical regime is shown. Respective λ values are shown as multiple of λ_fit (× 1, × 10, × 100). Horizontal lines show upper-bound and lower-bound estimates of β^∗ (β^∗_Ising = 0.138 and β^∗_{mean_field} = 0.0784, respectively). Dash line in (C) shows the low-bound estimate for open number of RyRs at a steady state (n_∞). Insets show β dynamics with respect to criticality in a more detailed y scale. Bottom panels show respective distributions of RyR states and Ca_dyad at t = 200 ms. Ca_dyad is coded by shades: from 0 to 30 μM (saturated). See also Videos S4 and S5. To see this figure in color, go online.