Figure 6.

Peierls contour distinguishes disorder leak and synchronized leak. (A and B) Time course of number of open RyRs and respective length of Peierls contour in spark termination failure via two different mechanisms are shown: the blue curve shows Ca leak in the supercritical regime (synchronized leak, τ_fill = 0.5); red curve shows Ca leak in the subcritical regime (disorder leak, λ = 100 × λ_fit). (C) Distribution of CRU states at time 200 ms. Ca_dyad is coded by shades: from 0 to 30 μM (saturated). Peierls contours are shown by white lines over open RyR clusters. See also Videos S6 and S7. To see this figure in color, go online.