Table 3.

Incidence rates and hazard ratios of emergency department visits and hospital admissions for hypoglycemia.

Exposure	New users a	Person years at risk	Serious hypoglycemia events	Incidence rate per 1,000 person years	Hazard Ratio (95% CI)
Data from 13 data partners
Unmatched b
Glyburide	198,550	89,719	1,685	19	1.11 (1.05–1.18)
Glipizide	379,507	244,094	5,406	22
Predefined covariates - Unconditional model c
Glyburide	173,655	83,108	1,633	20	1.35 (1.26, 1.45)
Glipizide	173,656	99,834	1,393	14
Predefined covariates - Conditional model d
Glyburide	173,655	38,986	1,064	27	1.36 (1.24, 1.49)
Glipizide	173,656	38,986	784	20
Data from 5 data partners in which the hdPS model converged and completed without errors
Unmatched b
Glyburide	139,113	58,075	905	16	1.26 (1.16, 1.38)
Glipizide	181,911	94,941	1,079	11
Predefined covariates - Unconditional model c
Glyburide	120,334	53,366	859	16	1.41 (1.27, 1.56)
Glipizide	120,335	61,552	666	11
Predefined covariates - Conditional model d
Glyburide	120,334	24,708	568	23	1.42 (1.25, 1.62)
Glipizide	120,335	24,708	399	16
hdPS - Unconditional model c
Glyburide	116,930	52,816	870	17	1.50 (1.36, 1.66)
Glipizide	116,931	62,526	644	10
hdPS - Conditional model d
Glyburide	116,930	24,494	581	24	1.49 (1.31, 1.70)
Glipizide	116,931	24,498	389	16
Predefined covariates and hdPS - Unconditional model c
Glyburide	116,639	52,713	868	17	1.49 (1.34, 1.65)
Glipizide	116,641	61,778	644	10
Predefined covariates and hdPS - Conditional model d
Glyburide	116,639	24,332	575	24	1.51 (1.32, 1.71)
Glipizide	116,641	24,333	382	16

hdPS – High dimensional propensity score; SD – Standard deviation.

^aPlease note, one Data Partner removed a small number of users that moved to administrative services only plans. Information from these users is included in Tables 1 and 2, but removed from subsequent tables.

^bPlease note, all models were stratified by Data Partner.

^cThe conditional models were stratified by the matched pair.

^dThe unconditional models were not stratified by the matched pair.