Table 2.

Hazard ratio and 95% CIs for component of the primary and secondary endpoints

	Febuxostat group (n = 537)	Non-febuxostat group (n = 533)	Hazard ratio (95% confidence interval)	P-value
Primary endpoint
Composite of death due to any cause, cerebrovascular disease, non-fatal coronary artery disease, heart failure requiring hospitalization, arteriosclerotic disease requiring treatment, renal impairment, and atrial fibrillation	125 (23.3)	153 (28.7)	0.750 (0.592–0.950)	0.017
Secondary endpoints
Death due to cerebral, cardiovascular, or renal disease	6 (1.1)	6 (1.1)	0.958 (0.314–2.926)	0.940
Cerebrovascular disease	9 (1.7)	7 (1.3)	1.271 (0.479–3.371)	0.630
Non-fatal coronary artery disease	4 (0.7)	7 (1.3)	0.559 (0.167–1.869)	0.345
Heart failure requiring hospitalization	9 (1.7)	12 (2.3)	0.699 (0.290–1.689)	0.427
Arteriosclerotic disease requiring treatment	2 (0.4)	3 (0.6)	0.644 (0.107–3.873)	0.631
Renal impairment	87 (16.2)	109 (20.5)	0.745 (0.562–0.987)	0.041
Atrial fibrillation	4 (0.7)	3 (0.6)	1.320 (0.292–5.968)	0.719
Death due to other causes	4 (0.7)	6 (1.1)	0.635 (0.179–2.253)	0.482
Hard endpoint: composite of death due to any cause, cerebrovascular disease, or non-fatal coronary artery disease	23 (4.3)	26 (4.9)	0.861 (0.492–1.506)	0.600

Values are presented as n (%).

CI, confidence interval.