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. 2019 May 31;10:570. doi: 10.3389/fphar.2019.00570

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Copyright © 2019 Lin, Wu, Huang, Jiang, Pan, Kang and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of nobiletin on collagen II and aggrecan expression in mouse chondrocytes. Cells were pretreated with various concentrations of nobiletin (0, 10, 20, and 40 μM, 24 h) before stimulation with IL-1β (10 ng/ml, 24 h). The expression of collagen II and aggrecan was assessed by Western blot analysis (A–C). Values represent mean ± SD of three independent experiments. Significant differences are indicated as *p < 0.05 and **p < 0.01, compared with control group. *p < 0.05 and **p < 0.01, compared with IL-1β group. ##p < 0.01, compared to the control group.