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. 2019 May 28;14:3753–3771. doi: 10.2147/IJN.S196651

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© 2019 Khan et al.

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(A) Schematic illustration of the formulation of lipid-coated cisplatin/oleanolic acid co-loaded calcium carbonate nanoparticles (CDDP/OA-LCC NPs); (B) TEM images of CDDP/OA-LCC NPs, scale bar: 500 nm; (C) In vitro cumulative release profiles of CDDP and OA from the CDDP/OA-LCC NPs in PBS (72 h) at pH 7.4; (D) In vitro cumulative release profiles of CDDP and OA from the CDDP/OA-LCC NPs in PBS (72 h) at pH 5.5.

Abbreviations: CDDP, cisplatin; DOPA, dioleoyl-in-glycerol-3-phosphate; OA, oleanolic acid; PEG-DSPE 2000, mono-methoxy polyethylene glycol 2000-distearoyl phosphatidylethanolamine; LCC, lipid coated calcium carbonate; NP, nanoparticles; HSPC, dehydrogenated soya phosphatidylcholine; PBS, phosphate buffer saline.