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. Author manuscript; available in PMC: 2019 Jun 7.
Published in final edited form as: J Invest Dermatol. 2008 Mar 6;128(8):1981–1990. doi: 10.1038/jid.2008.34

Figure 3. A schematic representation of the overall design of approach.

Figure 3.

TGF-α and insulin are two potent stimulators of human keratinocyte migration. Therefore, dual stimulation with both GFs was used to eliminate the factor-specific (FS) genes, such as insulin-specific genes involved in glucose uptake. TGF-β selectively inhibits TGF-α- or insulin-stimulated proliferation, and not migration, of human keratinocytes, preventing growth-specific (GS) gene expression. After two layers of “gene filtration”, motility-specific (MS) gene profiles are anticipated.