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. 2019 Jun 6;20:112. doi: 10.1186/s12931-019-1077-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Concentration-dependent induction of coughs to reach either C2 or C5. AITC cough challenge (Panels a and b), capsaicin cough challenge (Panels c and d). C2: the lowest concentrations of AITC or capsaicin which evoked two to four coughs; C5: the lowest concentrations of AITC or capsaicin which evoked five coughs or more. The solid lines with dots represent patients with chronic refractory cough (CRC) and the dashed lines with triangles represent healthy subjects