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. 2019 Jun 6;38:237. doi: 10.1186/s13046-019-1239-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — The molecular mechanism involved in lncRNA DLX6-AS1 affecting LCSCs by regulating STAT3 signaling pathway through affecting CADM1 promoter methylation. Down-regulation of lncRNA DLX6-AS1 inhibited CADM1 promoter methylation, increased CADM1 expression, and suppressed the activation of the STAT3 signaling pathway, and finally the expression of CD133 and CD13 in LCSCs were decreased and the progression of LCSCs was repressed. lncRNA DLX6-AS1, long non-coding RNA DLX6-AS1; CADM1, cell adhesion molecule; STAT3, signal transducer and activator of transcription 3; LCSC, liver cancer stem cells