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. 2019 Jun 7;38:239. doi: 10.1186/s13046-019-1249-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — NEO212 promotes mitochondrial dysfunction. a A2780 and SK-O-V3 cells treated with 100 μM TMZ, POH, TMZ + POH, NEO212 or DMSO for 48 h respectively were stained with MTG. Scale bars: 10 μm. b-c Mitochondria structure in A2780 and SK-O-V3 cells treated with 100 μM NEO212 or DMSO was observed by TEM. Scale bars: 0.5 μm. Mitochondrial shape and area were measured using Fiji Image J. d A2780 and SK-O-V3 cells were treated with 100 μM TMZ, POH, TMZ + POH, NEO212 or DMSO for 48 h respectively, and detected using JC-1 flow cytometry. The results shown are means ± SD; *p < 0.05; **p < 0.01; ***p < 0.001, NS = no significance