Fig. 5.

22q11.2 genomic matrix for heart, neural, craniofacial and immune phenotypes. The table represents proximal-distal alignment of forty-one characterized protein-coding genes in 22q11.2 deleted region and their apparent functions in neural, cognitive, cardiovascular, craniofacial, and immune development. The presence of a non-consensus polyA signal in SEPT5 gene results in read-through transcription into the downstream neighboring gene resulting in SEPT5-GP1BB transcript “Entrez Gene: SEPT5”. “++”: if there is evidence from human and/or mouse, “+” if the evidence is from in vitro data or an investigation in lower vertebrates, “−” if there is no evidence the gene affects this particular function, and “?” if the data is inconclusive