Table 5.
Correlation of TILs in the tumour central area (TCA) with clinicopathological characteristics in HCC
| Variable | TIL+/TCA | TIL−/TCA | p value |
|---|---|---|---|
| No. of patients | 20 | 38 | |
| Patient age, years | 0.476 | ||
| ≤ 60 | 6 (30.0%) | 15 (39.1%) | |
| > 60 | 14 (70.0%) | 23 (60.9%) | |
| Gender | 0.732 | ||
| Female | 15 (75.0%) | 30 (78.9%) | |
| Male | 5 (25.0%) | 8 (21.1%) | |
| Local tumour recurrence | 0.933 | ||
| Positive | 6 (30.0%) | 11 (28.9%) | |
| Negative | 14 (70.0%) | 27 (71.1%) | |
| Overall tumour recurrence | 0.546 | ||
| Positive | 9 (45.0%) | 14 (36.8%) | |
| Negative | 11 (55.0%) | 24 (63.2%) | |
| Metastases | 0.884 | ||
| Positive | 4 (20.0%) | 7 (18.4%) | |
| Negative | 16 (80.0%) | 31 (81.6%) | |
| Multiple tumour nodules | 0.100 | ||
| Positive | 18 (90.0%) | 27 (71.1%) | |
| Negative | 2 (10.0%) | 11 (28.9%) | |
| Tumour size (mm) | 0.206 | ||
| ≤ 50 | 2 (10.0%) | 9 (23.7%) | |
| > 50 | 18 (90.0%) | 29 (76.3%) | |
| R status | 0.148 | ||
| Positive | 15 (75.0%) | 34 (89.5%) | |
| Negative | 5 (25.0%) | 4 (10.5%) | |
| Angioinvasion | 0.717 | ||
| Positive | 11 (55.0%) | 19 (50.0%) | |
| Negative | 9 (45.0%) | 19 (50.0%) | |
| Lymphangiosis carcinomatosa | 0.057 | ||
| Positive | 9 (45.0%) | 30 (78.9%) | |
| Negative | 11 (45.0%) | 8 (21.1%) | |
| Histologic differentiation | 0.576 | ||
| Well | 3 (15.0%) | 8 (21.1%) | |
| Moderate/poor | 17 (85.0%) | 30 (78.9%) | |
| Pathologic T stage | 0.708 | ||
| T1/T2 | 9 (47.4%) | 20 (52.6%) | |
| T3/T4 | 10 (52.6%) | 18 (47.4%) | |
| Pathologic N stage | 0.296 | ||
| Positive | 0 (00.0%) | 2 (5.3%) | |
| Negative | 20 (100.0%) | 36 (94.7%) | |
| CD68+ TAMs/TCA | 0.008 | ||
| Positive | 20 (100.0%) | 11 (28.9%) | |
| Negative | 0 (00.0%) | 27 (71.1%) |