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. 2019 Jun 6;19:540. doi: 10.1186/s12885-019-5725-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Adjuvanted E7 SLP promotes antigen specific memory CD8 T cells durable T cell functionality. Mice (n = 5) were immunized s.c. on day 0 and 21 with 20 μg E7 SLP + CpG +/− o/w emulsion. Splenocytes and PBMCs were isolated on day 28. a Cells were FACS analyzed for presence of E7 dextramer⁺ CD62L- CD44^hi KLRG1^hi populations. b Mice (n = 5) were immunized s.c. on day 0 and 21 with 3 μg E7 SLP + o/w emulsion +/− CpG. Splenocytes were isolated approximately 3 months (day 111) and 6 months (day 202) post second immunization. Cells were stimulated in vitro with E7 ME peptide and analyzed via ELISpot for IFN-γ secretion. Two-sided hypothesis test for comparisons using one-way ANOVA model; ns, not significant; **, p < 0.01; ***, p < 0.001