Table 2.

The probability of target attainment (%PTA) of various fosfomycin monotherapy regimens.

	Probability %T>MIC>70%
	infusion 30 minutes						infusion 6 hours
CMI (mg/L)	2 g/6 h	4 g/12 h	4 g/8 h	4 g/6 h	6 g/6 h	8 g/8 h	4g/8 h	8g/8 h
0.03	100	100	100	100	100	100	100	100
0.06	100	100	100	100	100	100	100	100
0.13	100	100	100	100	100	100	100	100
0.25	100	100	100	100	100	100	100	100
0.5	100	100	100	100	100	100	100	100
1	100	100	100	100	100	100	100	100
2	100	100	100	100	100	100	100	100
4	100	100	100	100	100	100	100	100
8	100	100	100	100	100	100	100	100
16	100	97	100	100	100	100	100	100
32a	78	20	98	100	100	100	100	100
64	0	0	11	79	100	98	49	100
128	0	0	0	0	23	11	0	50
	Probability AUC24/MIC > 24 (for Enterobacterales)				Probability AUC24/MIC > 15 (for P. aeruginosa)
CMI (mg/L)	4 g/12 h	4 g/8 h	4 g/6 h	6g/6h 8g/8h	4 g/12 h	4 g/8 h	4 g/6 h	6g/6h 8g/8h
0.03	100	100	100	100	100	100	100	100
0.06	100	100	100	100	100	100	100	100
0.13	100	100	100	100	100	100	100	100
0.25	100	100	100	100	100	100	100	100
0.5	100	100	100	100	100	100	100	100
1	100	100	100	100	100	100	100	100
2	100	100	100	100	100	100	100	100
4	100	100	100	100	100	100	100	100
8	100	100	100	100	100	100	100	100
16	100	100	100	100	100	100	100	100
32a	98	100	100	100	100	100	100	100
64	4	71	99	100	81	100	100	100
128	0	0	4	71	0	24	82	100
256	0	0	0	0	0	0	0	24
Continuous infusion		12 g/day		16 g/day
Probability Css > 32 mg/L		100		100
Probability Css > 64 mg/L		70		98
Probability Css > 128 mg/L		0		4

In gray, values ≥90%, in bold, values ≥80 and <90%. aFosfomycin EUCAST breakpoint.