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. 2019 May 31;12:142. doi: 10.3389/fnmol.2019.00142

FIGURE 6.

FIGURE 6

Genotype effects on arachidonic acid-derived CNS lipids. Heatmaps show effects of ABHD12 deletion on levels of arachidonic acid and targeted arachidonic acid-derived lipids in the striatum (STR), hippocampus (HIPP), cerebellum (CER), thalamus (THAL), cortex (CTX), hypothalamus (HYP), midbrain (MID), and brainstem (STEM). Cells with shaded arrows indicate a change for that lipid in the indicated ABHD12 knockout (KO) brain area relative to the same wild-type (WT) control area. The arrow color indicates the direction of a significant result in the KO brain area relative to WT. Green colors represent increases, whereas orange colors represent decreases. Darker colors represent changes of p < 0.05 and lighter colors represent changes of p < 0.10. The number of arrows indicates the magnitude of the difference. One arrow indicates a magnitude difference of less than 1.5 fold, 2 arrows indicate a 1.5–1.99 fold change, and 3 arrows indicate a 2–2.99 fold change. A blank cell indicates that there was no change in the lipid’s level. BAL, below analytical limit; meaning that the indicated analyte was not detected in all samples from that region. See Methods and Supplementary Figure 2 for more detailed description of analysis. (A) Effects of genotype in younger adult animals. (B) Effects of genotype in older adult animals. (C) ABHD12 KO (young and older adult animals combined) compared to WT (young and older adult animals combined).