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. 2019 May 31;12:142. doi: 10.3389/fnmol.2019.00142

FIGURE 7.

FIGURE 7

Age effects on arachidonic acid-derived CNS lipids. Heatmaps show effects of age on levels of arachidonic acid and arachidonic acid-derived lipids in the striatum (STR), hippocampus (HIPP), cerebellum (CER), thalamus (THAL), cortex (CTX), hypothalamus (HYP), midbrain (MID), and brainstem (STEM). Cells with shaded arrows indicate a change for that lipid in the indicated older adult brain area relative to the same younger adult area. The arrow color indicates the direction of a significant result in the older adult brain region relative to younger adult levels in the same region. Green colors represent increases, whereas orange colors represent decreases. Darker colors represent changes of p < 0.05 and lighter colors represent changes of p < 0.10. The number of arrows indicates the magnitude of the difference. One arrow indicates a magnitude difference of less than 1.5 fold, 2 arrows indicate a 1.5–1.99 fold change, and 3 arrows indicate a 2–2.99 fold change. A blank cell indicates that there was no change in the lipid’s level due to age. BAL, below analytical limits. See Methods and Supplementary Figure 2 for more detailed description of analysis. (A) Shows the effect of aging in wild-type (WT) mice, whereas (B) shows the effect of aging in ABHD12 knockout (KO) mice. (C) Shows the comparison between older adult mice (WT and ABHD12 KO combined) and younger adult mice (WT and ABHD12 KO combined).