Table 2.

FLT-PET-CT scan and confirmation of disease recurrence.

Patient	SUVmax lesion-FDG	SUVmax lesion-FLT	SUV mediastinal blood pool-FLT	Ratio of SUVmax lesion-FLT and SUVmax mediastinal blood pool-FLT	Focality of lesion on FLT	Recurrence prediction based on radiologist interpretation of FLT**	Recurrence confirmation by biopsy or serial imaging
1	3.4	3.9	1.0	3.9	No	Recurrence	Recurrence*
2	10	3.7	0.8	4.6	Yes	Recurrence	Recurrence*
3	6	2.0	1.6	1.3	No	No Recurrence	Recurrence*
4	6.8	5.9	0.7	8.4	Yes	Recurrence	Recurrence†
5	4.2	1.7	1.0	1.7	No	No Recurrence	N/A
6	2.4	1.3	0.9	1.4	No	No Recurrence	No Recurrence†
7	4.1	1.6	1.2	1.3	No	No Recurrence	N/Aa
8	3.6	2.1	1.1	1.9	No	No Recurrence	No Recurrence*
9	6.0	2.8	0.7	4.0	Yes	Recurrence	Recurrence*
10	4.2	1.5	0.6	2.5	No	No Recurrence	No Recurrence†

FLT-PET correctly predicted recurrence status in 7 of 8 assessable cases. Combination of both lesion FLT SUV_max > 2.0 plus ratio of lesion FLT SUV_max and mediastinal blood pool FLT SUV_max > 2.0 is indicative of disease recurrence.

^*Biopsy;

^†serial imaging;

^**radiologist interpreting FLT-PET scans was blinded to biopsy results and subsequent imaging. N/A: Patient died of unrelated causes before final determination of disease status could be achieved by biopsy or serial imaging.

^aAlthough final determination of disease status could not be achieved, lesion remained stable in size and FDG avidity on follow-up FDG-PET scan, 4 months after FLT-PET-CT.