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The balance between pro-inflammatory and protective B cell functions.
| Induce autoimmunity | Suppress autoimmunity | |
|---|---|---|
| •T cell activation | •T cell anergy | |
| •Th1 cytokines (Be 1) | •Th2 cytokines (Be2) | |
| •Treg inhibition | •Treg priming/expansion | |
| •DC recruitment | •DC inhibition (IL-10) | |
| •Pathogenic Autoab | •Protective Ab | |
| •Pro-inflammatory cytokines | •Anti-inflammatory cytokines | |
| TNF, IFNγ, IL-12p40, IL-6 | •Formation of ectopic lymphoid tissue | IL-10, TGFβ |
