Figure 5.

The progression of DNAm age after more than 10 PD of fibroblasts from donors of different ages from. (A and B) The progression of DNAmAge^391CpG (A) and DNAmAge^353CpG (B) after more than 10 PD of cell culture is shown. Each panel shows the following information: (A and B) Changes of DNAm age after more than 10 PD. (C and D) The Y axis indicates the values of DNAmAge^391CpG/PD (C) and DNAmAge^353CpG/PD (D). The X-axis indicates the DNAm age at the beginning of this experiment. The impact of PD on the speed of DNAm age progression becomes greater when the starting DNAmAge^391CpG is older, but becomes lesser when the starting DNAmAge^353CpG is older. The dots with the same color are the results from the same cell line.