Methods | Study design: randomized controlled trial Study dates: 1969 to 1971 Diagnostics: clinical diagnosis and serological or virological. Haemagglutination inhibition (HI) test performed on paired sera; positive result was a fourfold rise in titre or a fixed level at 1:640 or more. |
|
Participants | Number of participants: randomized: 26 enrolled (7 in corticosteroid group;
19 in control group) Age: 6.6 to 9.5 years Inclusion criteria: children diagnosed with dengue shock syndrome using serological confirmation Exclusions: not specified |
|
Interventions | 1. Hydrocortisone hemisuccinate: intravenous 25 mg/kg/day; 5 mg/kg at
start, rest given in divided doses every four to six hours in addition to
fluid replacement 2. No medication (fluid replacement only) |
|
Outcomes | 1. Death 2. Duration of shock 3. Number requiring fluid replacement 4. Number needing blood transfusion |
|
Notes | Location: Ramathibodi Hospital, Bangkok, Thailand Transmission: not specified Funding: not specified |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "A card was drawn at onset of shock to decide which treatment program would be given", no more detail about sequence generation |
Allocation concealment (selection bias) | Unclear risk | Not specified |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not specified |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not specified |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No losses to follow‐up were reported |
Selective reporting (reporting bias) | Low risk | No evidence of selective reporting |
Other bias | Low risk | No other bias identified |