Table 4. Factors Associated With Recurrence of Immune-Related Adverse Events (iRAEs) in Patients After Anti–PD-1 or Anti–PD-L1 Rechallenge .
| Variable | irAE Recurrence (n = 22) | No irAE Recurrence (n = 18) | P Value |
|---|---|---|---|
| Age, median (range), y | 63 (32-84) | 57 (33-84) | .44 |
| Sex, No. (%) | |||
| Male | 9 (41) | 9 (50) | .75 |
| Female | 13 (59) | 9 (50) | |
| Time to the irAE, median (range) | |||
| Treatment cycle | 4 (1-13) | 6 (1-40) | .09 |
| Week | 9.15 (0.6-41) | 15 (2-99) | .04a |
| Grade of the initial irAE, No. (%) | |||
| G2 | 7 (32) | 11 (61) | .10 |
| G3-4 | 15 (68) | 7 (39) | |
| Corticosteroid use, No./No. (%) | 12/22 (55) | 4/18 (22) | .06 |
| Death related to irAE, No. (%) | 0 (0) | 0 (0) | |
| Previous ICI, No. (%) | 2 (4.5) | 2 (11) | >.99 |
| Tumor type/site, No. (%) | |||
| Melanoma | 6 (27) | 5 (28) | .48 |
| Lymphoma | 5 (23) | 1 (6) | |
| Non–small cell lung carcinoma | 3 (14) | 4 (22) | |
| Head and neck | 0 (0) | 2 (11) | |
| Colorectal cancer | 3 (14) | 3 (17) | |
| Others | 5 (23) | 3 (17) | |
| Baseline laboratory values | |||
| LDH, IU/mL | 212 | 166 | .06 |
| CRP, mg/L | 13 | 6 | .55 |
| Albumin, g/L | 40 | 40 | .26 |
| Neutrophils, /μL | 4350 | 3950 | .67 |
| Lymphocytes, /μL | 900 | 1200 | .56 |
| Platelets, /μL | 239 000 | 216 500 | .68 |
| Laboratory values at the time of irAE | |||
| LDH, IU/mL | 221 | 189 | .04a |
| CRP, mg/L | 11 | 26 | .56 |
| Albumin, g/L | 40 | 39 | .86 |
| Neutrophils, /mm3 | 4750 | 4150 | .95 |
| Lymphocytes, /mm3 | 1100 | 1300 | .61 |
| Platelets, /mm3 | 193 500 | 237 000 | .50 |
Abbreviations: CRP, C-reactive protein; ICI, immune checkpoint inhibitor; LDH, lactate dehydrogenase; PD-1, programmed cell death 1; PD-L1, programmed cell death 1 ligand 1.
SI conversion factors: To convert lactate dehydrogenase to microkatals per liter, multiply by 0.0167; C-reactive protein level to nanomoles per liter, multiply by 9.524; neutrophils to × 109 per liter, multiply by 0.001; lymphocytes to × 109 per liter, multiply by 0.001; and platelets to × 109 per liter, multiply by 0.001.
a
Statistically significant (P < .05).