Fig 2. Interaction of m⁷GTP with RVFV CBD.

A) The figure shows binding of m⁷GTP to RVFV CBD chain A in the crystal. RVFV CBD is presented as a ribbon diagram with the side chains of the two aromatic residues typical for binding of cap-structures shown as sticks. m⁷GTP is presented as lines and the surrounding electron density (2|Fo|-|Fc| omit map at 1.5σ) as grey mesh. Secondary structure elements are labelled. B) Amino acid side chains interacting with the m⁷GTP ligand (presented as lines) are shown as sticks. The structure of RVFV CBD chain A is indicated in grey. A detailed list of interactions is given in S2 Table. C) A close-up of the m⁷GTP binding site is presented. The protein is shown as ribbon diagram, involved side chains as sticks and the m⁷GTP as lines. The residues are grouped and colored according to A) and their role in the interaction with m⁷GTP.