Fig 3. Alignment of the phlebo- and banyangvirus cap-binding domain.

22 sequences of phlebo- and banyangvirus cap-binding domains (Uniprot accession numbers are given) were aligned by manually combining ClustalOmega and PRALINE programs [53–56] and presented by ESPript (http://espript.ibcp.fr) [57]. Residue numbers refer to RVFV strain ZH-501 full-length L protein. Secondary structure elements of RVFV ZH-501 according to the RVFV CBD structure are depicted below the sequences. Residues involved in the cap-binding site are labelled with the same color code as used in Fig 2C.