Recommended doses for elderly patients
	Dabigatran	Rivaroxaban	Apixaban	Endoxaban
Commercial presentation	150 mg 110 mg	20 mg 15 mg 10 mg	5 mg 2.5 mg	30 mg 60 mg
Dose	150 mg CrCl > 50 ml/min	20 mg CrCl > 50 ml/min	5 mg CrCl > 30 ml/min	60 mg CrCl > 50 ml/min
	110 mg CrCl between 30 and 50 ml/min	15 mg CrCl between 30 and 50 ml/min	2.5 mg CrCl 15-30 ml/min or Two of the following criteria: ≥ 80 years old Weight ≤ 60 kg Creatinine ≥ 1.5 mg	30 mg CrCl 15-50 ml/min or weight ≤ 60 kg
Posology	2 x day	1 x day	2 x day	1 x day
Particularities	Dyspepsia is common	Higher risk of GI bleeding than warfarin
	Avoid if CrCl < 30 ml/min), recent stroke, and severe active hepatic disease	Avoid if CrCl < 15 ml/min) and severe active hepatic disease	Avoid if CrCl < 15 ml/min) or Creatinine > 2.5 mg and severe active hepatic disease	Avoid if CrCl < 15 ml/min or severe hepatic disease

CrCl: creatinine clearance; GI: gastrointestinal. Source: European Heart Journal.³²⁴