Date	Event	Description
30 June 2015	Amended	Added revised data including (smear positive culture negatives) for Boehme 2010 and Rachow. Added corrected data for Hanrahan. Added test and analysis for Hx of TB. Amended patient selection for Boehme 2011 to high risk of bias.
16 March 2015	Feedback has been incorporated	Feedback from Dr Tom Boyles at University of Cape Town has been incorporated and responded to.
6 May 2014	Amended	Following information from one of the trial authors, details of the version of Xpert MTB/RIF used in Balcells 2012 have been corrected.
13 February 2014	Amended	Sentence moved in abstract; corrected 'pooled median sensitivity' to 'median pooled sensitivity' throughout.
30 November 2013	New search has been performed	1. We performed an updated literature search on 7 February 2013. 2. For smear microscopy as a comparator test, we added a descriptive plot showing the estimates of sensitivity and specificity of Xpert compared with those of smear microscopy in studies that reported on both tests. 3. We included studies using Xpert version G4 (two studies) and studies evaluating Xpert in primary care clinics (two studies). These studies did not change the overall findings. 4. We improved the QUADAS‐2 assessment concerning applicability. 5. For TB detection, we repeated our earlier meta‐regression analyses within subgroups defined by smear status. 6. For rifampicin resistance detection, we performed univariate meta‐analyses for sensitivity and specificity separately in order to include studies in which no rifampicin resistance was detected. We also performed a sensitivity analysis using the bivariate random‐effects model for the subset of studies that provided data for both sensitivity and specificity. 7. We revised the summary of findings table to include clinical scenarios with prevalence levels recommended by the World Health Organization. 8. In the Background, we shortened the section on alternative tests to include only those tests most relevant to the review. 9. We added health economic considerations to the Discussion. 10. We added updated TB surveillance information.
30 November 2013	New citation required but conclusions have not changed	We conducted a new search and revised the review as described.
17 January 2013	Amended	We made some minor edits to the text to correct typographical errors. In addition, we replaced Figures 6, 8, 11, and 13 with new figures with minor modifications to the prediction regions.