Barmankulova 2015
| Study characteristics | |||
| Patient sampling | Cross‐sectional design, unknown manner of enrolment, direction of data collection unclear | ||
| Patient characteristics and setting | Presenting signs and symptoms: at least 2 weeks of cough, accompanied with loss of weight, night sweats and fever in labour migrants Age: median 34 years (IQR 25 to 45) Sex, female: 43% HIV infection: not reported History of TB: 25% Sample size: 291 Clinical setting: outpatient Laboratory level: intermediate and central Country: Kyrgyzstan World Bank Income Classification: middle income High TB burden country: no High MDR‐TB burden country: yes High TB/HIV burden country: no Prevalence of TB cases in the study: 80.8% |
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| Index tests | Index: Xpert MTB/RIF | ||
| Target condition and reference standard(s) | Target condition: pulmonary TB Reference standard for pulmonary TB: LJ and MGIT 960 Target condition: rifampicin resistance Reference standard for rifampicin resistance LJ and MGIT 960 |
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| Flow and timing | 43 participants without microscopy results and 3415 participants without culture results were not included | ||
| Comparative | |||
| Notes | "Migrants in the TB REACH project are defined as labour migrants who registered in one region but are working and living permanently in another region without registration and any access to primary healthcare facilities." | ||
| Methodological quality | |||
| Item | Authors' judgement | Risk of bias | Applicability concerns |
| DOMAIN 1: Patient Selection | |||
| Was a consecutive or random sample of patients enrolled? | Unclear | ||
| Was a case‐control design avoided? | Yes | ||
| Did the study avoid inappropriate exclusions? | Yes | ||
| Unclear | Low | ||
| DOMAIN 2: Index Test Xpert MTB/RIF | |||
| Were the index test results interpreted without knowledge of the results of the reference standard? | Yes | ||
| If a threshold was used, was it pre‐specified? | Yes | ||
| Low | Low | ||
| DOMAIN 3: Reference Standard | |||
| Is the reference standards likely to correctly classify the target condition? | Yes | ||
| Were the reference standard results for TB detection interpreted without knowledge of the results of the index test? | Yes | ||
| Were the reference standard results for rifampicin resistance detection interpreted without knowledge of the results of the index test? | Yes | ||
| Low | Unclear | ||
| DOMAIN 4: Flow and Timing | |||
| Was there an appropriate interval between index test and reference standard? | Yes | ||
| Did all patients receive the same reference standard? | Yes | ||
| Were all patients included in the analysis? | No | ||
| High | |||