Table 3.

Univariate analysis for tumour-specific survival in stages I–III

	HR	95% CI	P value
Gender (male)	0.91	0.55 to 1.50	0.71
MSI	0.43	0.05 to 0.10	0.03
EBER-positive	1.13	0.40 to 3.14	0.81
pT3–4 vs 1–2	1.67	0.78 to 3.57	0.18
Nodal metastasis	2.56	1.17 to 5.59	0.01
Distal location	0.53	0.32 to 0.86	0.01
LV invasion	1.41	0.70 to 2.86	0.32
Histological subtype
Diffuse (vs intestinal)	1.00	0.57 to 1.75	0.98
Mixed (vs intestinal)	0.92	0.39 to 2.15	0.84
Tumour location-modified Lauren classification
D (vs PND)	0.58	0.32 to 1.03	0.06
DND (vs PND)	0.42	0.23 to 0.75	0.003

Significant p-values are shown in bold

D, diffuse; DND, distal non-diffuse; EBER, Epstein-Barr virus-encoded small RNAs; LV, lymphovascular; MSI, microsatellite instability; PND, proximal non-diffuse.