Table 2.
Hepatic gene expression for AhR, CAR and PXR and their targets was measured using RT-PCR. Values are mean ± SD. Values for p <0.05 are in bold.
| Outcome (Fold induction) | Female-CON | Female-PCBs | Male-CON | Male-PCBs |
|---|---|---|---|---|
| Cyp1a2 | 4.1 ± 8.3 | 33.8 ± 16.1 | 1.1 ± 0.6 | 23.1 ± 6.2 |
| AhR | 0.7 ± 0.3 | 0.4 ± 0.3 | 1.0 ± 0.3 | 0.7 ± 0.1 |
| Cyp3a11 | 2.5 ± 0.6 | 3.7 ± 2.1 | 1.2 ± 0.9 | 1.6 ± 0.4 |
| Nr1i2 | 1.8 ± 0.7 | 0.7 ± 0.4 | 1.3 ± 0.6 | 1.3 ± 0.3 |
| Cyp2b10 | 459.4 ± 261.0 | ±3027.0 | 9.1 ± 13.6 | 871.8 ±696.9 |
| Cyp2c29 | 3.9 ± 3.6 | 14.6 ± 11.2 | 1.1 ± 0.4 | 4.4 ± 2.4 |
| Nr1i3 | 1.2 ± 0.4 | 0.8 ± 0.5 | 1.1 ± 0.5 | 2.5 ± 0.7 |
| p-value | |||||||
|---|---|---|---|---|---|---|---|
| Outcome | Sex | PCBs | Inter-action | Female (Con vs. PCBs) | Male (Con vs. PCBs) | Con (Male vs. Female) | PCBs (Male vs. Female) |
| Cyp1a2 | 0.024 | 0.000 | 0.628 | 0.000 | 0.000 | 0.045 | 0.205 |
| Ahr | 0.002 | 0.000 | 0.180 | 0.000 | 0.052 | 0.142 | 0.002 |
| Cyp3a11 | 0.000 | 0.017 | 0.620 | 0.154 | 0.047 | 0.000 | 0.001 |
| Nr1i2 | 0.576 | 0.075 | 0.010 | 0.002 | 0.539 | 0.126 | 0.027 |
| Cyp2b10 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.007 |
| Cyp2c29 | 0.000 | 0.000 | 0.727 | 0.000 | 0.000 | 0.000 | 0.001 |
| Nr1i3 | 0.001 | 0.219 | 0.000 | 0.047 | 0.001 | 0.720 | 0.000 |