Figure 9. The first NIR-II molecular imaging-guided tumor surgery.
a) Reaction scheme of NIR-II conjugate CH1055@affibody. b) Targeted cell staining indicated the successful conjugation of CH1055 with EGFR affibody. c-d) NIR-II imaging with tail injection of CH1055@affibody conjugate showed great targeting ability. e) The imaging-guided surgery can remove the tumor via complete excision. f) T/NT ratios with CH1055-affibody targeted tumor imaging. Reprinted with permission from Ref. [88].