Table 3.
Genetic association results for metabolic syndrome component traits in females. Overall association results were obtained from meta-analyses combining KARE, Rural1816, Rural3667, and HEXA studies
| Trait | CHR | SNP | BP (GRCh37) | Candidate gene | EA | EAF | Overall meta (female) | Overall meta (male) | Overall meta (male+female) | Association with MetS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BETA | SE | P meta | P Het | N | BETA | SE | P meta | BETA | SE | P meta | P KARE-female | |||||||
| Genetic loci showing strong evidence of association for MetS component traits in females (Pmeta < 5X10−8) | ||||||||||||||||||
| FPG | 21 | rs455489 | 41,939,569 | DSCAM | C | 0.02 | 6.76 | 1.14 | 2.92E-09 | 0.53 | 7442 | 0.51 | 1.42 | 7.18E-01 | 4.03 | 0.91 | 9.14E-06 | 7.07E-02 |
| HDLC | 11 | rs7115583 | 116,784,376 | SIK3 | T | 0.15 | 1.32 | 0.24 | 3.58E-08 | 0.20 | 6905 | 0.46 | 0.27 | 8.79E-02 | 0.94 | 0.18 | 2.30E-07 | 1.61E-01 |
| Genetic loci showing moderate evidence of association for MetS component traits in females (5X10− 8 < Pmeta < 10−5) | ||||||||||||||||||
| WC | 1 | rs6683379 | 223,906,421 | CAPN2 | A | 0.48 | −0.65 | 0.14 | 8.05E-06 | 0.88 | 6690 | 0.09 | 0.14 | 5.11E-01 | − 0.35 | 0.11 | 9.53E-04 | 3.44E-01 |
| 8 | rs921449 | 34,967,179 | LOC105379369 | A | 0.32 | 0.58 | 0.13 | 9.29E-06 | 0.74 | 9819 | −0.08 | 0.13 | 5.31E-01 | 0.27 | 0.10 | 6.65E-03 | 6.88E-01 | |
| 20 | rs6029818 | 40,409,163 | CHD6 | A | 0.24 | 0.63 | 0.14 | 8.47E-06 | 0.85 | 9779 | 0.04 | 0.14 | 7.58E-01 | 0.30 | 0.11 | 4.43E-03 | 3.20E-01 | |
| FPG | 2 | rs10171377 | 77,437,279 | LRRTM4 | G | 0.31 | −1.13 | 0.25 | 8.19E-06 | 0.54 | 6556 | −0.16 | 0.32 | 6.28E-01 | − 0.68 | 0.20 | 6.98E-04 | 6.93E-01 |
| 3 | rs6801331 | 124,918,754 | SLC12A8 | T | 0.11 | 1.59 | 0.36 | 8.45E-06 | 0.87 | 9786 | 0.30 | 0.46 | 5.16E-01 | 1.04 | 0.29 | 2.97E-04 | 1.10E-02 | |
| 8 | rs7821492 | 77,823,083 | ZFHX4/PEX2 | C | 0.02 | 8.02 | 1.56 | 2.77E-07 | 0.13 | 7202 | 2.06 | 1.76 | 2.42E-01 | 5.33 | 1.19 | 7.33E-06 | 5.50E-01 | |
| 10 | rs12783001 | 65,091,110 | JMJD1C | C | 0.02 | 6.81 | 1.50 | 5.36E-06 | 0.55 | 7481 | 1.37 | 1.69 | 4.16E-01 | 4.32 | 1.14 | 1.52E-04 | 8.35E-01 | |
| 11 | rs571911 | 126,481,440 | KIRREL3 | C | 0.42 | −1.76 | 0.37 | 1.94E-06 | 0.50 | 7497 | −0.28 | 0.43 | 5.13E-01 | −1.13 | 0.29 | 7.87E-05 | 8.41E-01 | |
| 12 | rs17125610 | 62,392,548 | FAM19A2 | A | 0.10 | 2.59 | 0.58 | 9.33E-06 | 0.95 | 7453 | −0.26 | 0.70 | 7.11E-01 | 1.25 | 0.46 | 6.23E-03 | 6.18E-01 | |
| SBP | 5 | rs10474306 | 89,069,875 | LOC105379076 | G | 0.14 | 1.70 | 0.38 | 9.37E-06 | 0.72 | 7531 | −0.29 | 0.39 | 4.60E-01 | 0.78 | 0.28 | 5.19E-03 | 1.29E-01 |
| 5 | rs316224 | 96,414,272 | LIX1-AS1 | A | 0.29 | 1.30 | 0.29 | 9.72E-06 | 0.76 | 7660 | −0.17 | 0.30 | 5.61E-01 | 0.65 | 0.21 | 2.06E-03 | 3.90E-01 | |
| 6 | rs393628 | 5,109,119 | LYRM4 | T | 0.09 | 1.97 | 0.44 | 7.75E-06 | 0.83 | 6657 | 0.11 | 0.48 | 8.19E-01 | 1.20 | 0.33 | 2.67E-04 | 4.14E-01 | |
| 7 | rs4419754 | 79,337,748 | LOC105375370 | C | 0.05 | −2.86 | 0.58 | 7.30E-07 | 0.66 | 6700 | −0.53 | 0.62 | 3.91E-01 | −1.78 | 0.43 | 3.20E-05 | 1.94E-01 | |
| 15 | rs16973236 | 82,235,114 | LOC102724001 | G | 0.17 | 1.69 | 0.38 | 7.20E-06 | 0.62 | 6668 | 0.23 | 0.40 | 5.68E-01 | 0.99 | 0.28 | 3.72E-04 | 6.21E-02 | |
| 17 | rs3888658 | 64,473,272 | PRKCA | A | 0.31 | −1.30 | 0.29 | 7.17E-06 | 1.00 | 7657 | 0.37 | 0.30 | 2.09E-01 | −0.51 | 0.21 | 1.45E-02 | 5.46E-01 | |
| DBP | 12 | rs7315532 | 9,483,063 | LOC105369649 | C | 0.37 | 0.79 | 0.18 | 9.89E-06 | 0.81 | 7654 | −0.11 | 0.19 | 5.65E-01 | 0.40 | 0.13 | 2.17E-03 | 4.30E-01 |
| 14 | rs2415841 | 44,650,411 | LINC02307 | C | 0.05 | 1.82 | 0.39 | 2.21E-06 | 0.82 | 6647 | −0.09 | 0.43 | 8.36E-01 | 1.04 | 0.29 | 4.06E-04 | 4.17E-01 | |
| 16 | rs1364120 | 83,740,126 | CDH13 | G | 0.32 | −0.77 | 0.17 | 6.30E-06 | 0.80 | 6904 | −0.02 | 0.20 | 9.10E-01 | −0.43 | 0.13 | 1.06E-03 | 2.21E-01 | |
| HDLC | 11 | rs11216315 | 117,080,640 | PCSK7 | G | 0.13 | 1.17 | 0.26 | 6.87E-06 | 0.78 | 7649 | 0.39 | 0.28 | 1.64E-01 | 0.82 | 0.19 | 1.84E-05 | 6.30E-01 |
| 13 | rs4883839 | 69,720,694 | na | T | 0.28 | 0.85 | 0.19 | 7.87E-06 | 0.29 | 7633 | 0.14 | 0.20 | 4.92E-01 | 0.51 | 0.14 | 2.71E-04 | 1.53E-02 | |
| 16 | rs6497373 | 19,460,842 | TMC5 | A | 0.16 | −1.04 | 0.23 | 8.45E-06 | 0.46 | 7650 | 0.02 | 0.25 | 9.31E-01 | −0.61 | 0.17 | 4.15E-04 | 5.78E-01 | |
| 18 | rs11082766 | 47,132,464 | LIPG | T | 0.27 | 0.96 | 0.19 | 6.89E-07 | 0.27 | 7649 | 0.24 | 0.21 | 2.45E-01 | 0.60 | 0.14 | 3.39E-05 | 6.26E-01 | |
| 19 | rs6508974 | 41,733,145 | AXL | C | 0.37 | 0.87 | 0.18 | 1.09E-06 | 0.63 | 7652 | −0.06 | 0.19 | 7.39E-01 | 0.44 | 0.13 | 8.21E-04 | 3.74E-03 | |
| 20 | rs6046295 | 19,727,038 | SLC24A3/RIN2 | A | 0.05 | 1.58 | 0.35 | 4.40E-06 | 0.11 | 9819 | −0.34 | 0.39 | 3.89E-01 | 0.66 | 0.26 | 1.12E-02 | 1.13E-01 | |
| TG | 1 | rs3766235 | 47,049,747 | MKNK1 | C | 0.03 | 17.81 | 3.95 | 6.57E-06 | 0.30 | 6893 | 3.46 | 6.86 | 6.15E-01 | 11.45 | 3.72 | 2.08E-03 | 7.11E-01 |
| 1 | rs11208004 | 63,145,439 | DOCK7 | A | 0.17 | −8.10 | 1.82 | 9.13E-06 | 0.42 | 6730 | −5.56 | 2.98 | 6.19E-02 | −7.30 | 1.67 | 1.27E-05 | 7.06E-01 | |
| 5 | rs1092913 | 10,467,702 | ROPN1L | G | 0.29 | 7.54 | 1.46 | 2.33E-07 | 0.32 | 7658 | 1.69 | 2.26 | 4.54E-01 | 5.08 | 1.34 | 1.49E-04 | 2.09E-01 | |
| 6 | rs3132722 | 29,867,174 | LOC105375010 | T | 0.26 | 6.90 | 1.54 | 7.61E-06 | 0.81 | 6629 | 4.63 | 2.51 | 6.48E-02 | 6.17 | 1.42 | 1.37E-05 | 2.60E-01 | |
| 9 | rs1381151 | 24,957,550 | na | A | 0.12 | 9.14 | 2.05 | 8.24E-06 | 0.56 | 6876 | −0.75 | 3.35 | 8.24E-01 | 4.84 | 1.89 | 1.02E-02 | 8.20E-01 | |
| 12 | rs710698 | 70,369,918 | MYRFL | G | 0.30 | 6.85 | 1.49 | 4.34E-06 | 0.52 | 6664 | 3.58 | 2.44 | 1.42E-01 | 5.62 | 1.37 | 4.27E-05 | 1.88E-01 | |
| 14 | rs17124780 | 52,425,506 | GNG2 | G | 0.29 | −6.73 | 1.24 | 5.52E-08 | 0.33 | 9920 | −1.09 | 2.02 | 5.87E-01 | −4.35 | 1.15 | 1.55E-04 | 6.47E-01 | |
| 16 | rs179604 | 13,814,473 | SHISA9/ERCC4 | T | 0.49 | −5.89 | 1.33 | 9.47E-06 | 0.16 | 7655 | 0.76 | 2.05 | 7.12E-01 | −2.73 | 1.22 | 2.48E-02 | 1.58E-01 | |
| 22 | rs1065314 | 33,258,288 | SYN3/TIMP3 | C | 0.06 | 14.58 | 2.82 | 2.41E-07 | 0.44 | 6738 | 0.62 | 4.55 | 8.92E-01 | 8.12 | 2.57 | 1.61E-03 | 3.48E-01 | |
Information for the SNP ID and chromosomal position is based on NCBI genome build 37/hg19
CHR chromosome, BP Physical position (base-pair), EA effect allele, EAF effect allele frequency, SE standard error, PHet heterogeneity p-value, N sample size, WC waist circumference, FPG fasting plasma glucose, SBP systolic blood presure, DBP diastolic blood presure, HDLC high density lipoprotein cholesterol, TG triglyceride