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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: J Mol Cell Cardiol. 2019 Mar 22;130:49–58. doi: 10.1016/j.yjmcc.2019.03.015

Figure 3. Effects of cardiomyocyte ADK disruption on LV function during pressure overload.

Figure 3

(A) Echocardiography measurements of end systolic diameter (ESD), (B) end diastolic diameter (EDD) and (C) ejection fraction (EF) 6 weeks after sham or TAC surgery. (n=10, 11, 12, and 14 for WT. ADK−/−, WT-TAC, and ADK−/−-TAC, respectively) (D) Lung weight to body weight ratio in WT and cADK−/− mice 6 weeks after TAC (n= 26, 24, 17, and 17 for, WT, ADK−/−, WT-TAC, and ADK−/−-TAC, respectively). (E) Left ventricular end systolic and (F) diastolic pressures and rates of LV pressure development during (G) systole and (H) diastole in WT and cADK−/− mice after TAC. (n=8, 9, 6, and 10 for WT. ADK−/−, WT-TAC, and ADK−/−-TAC, respectively)